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3SRK

A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase

Summary for 3SRK
Entry DOI10.2210/pdb3srk/pdb
Related1PKL
DescriptorPyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ... (5 entities in total)
Functional Keywordstim barrel, sugar kinase, phospho transfer, phosphenolpyruvate, transferase-inhibitor complex, transferase/inhibitor
Biological sourceLeishmania mexicana
Total number of polymer chains2
Total formula weight109981.13
Authors
Primary citationMorgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
To be Published,
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

PDB entries from 2024-03-27

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