4HYW

Pyruvate kinase (PYK) from Trypanosoma brucei in the presence of Magnesium and F26BP

Summary for 4HYW

Entry DOI	10.2210/pdb4hyw/pdb
Related	3HQN 3HQO 3HQP 3HQQ 3PP7 3QV6 3QV7 3QV8 3SRK 4HYV
Descriptor	Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	allosteric regulation, tetramer, pyruvate kinase, fructose-2, 6-diphosphate binding, phosphoenolpyruvate binding, cytosol, transferase
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	2
Total formula weight	110013.70
Authors	Zhong, W.,Morgan, H.P.,McNae, I.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2012-11-14, release date: 2013-09-11, Last modification date: 2024-02-28)
Primary citation	Zhong, W.,Morgan, H.P.,McNae, I.W.,Michels, P.A.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. `In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase. Acta Crystallogr.,Sect.D, 69:1768-1779, 2013 Cited by PubMed: 23999300 DOI: 10.1107/S0907444913013875 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation