4B7P

Structure of HSP90 with NMS-E973 inhibitor bound

Summary for 4B7P

Related1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2JJC 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 4AIF 4AWO 4AWP 4AWQ
DescriptorHEAT SHOCK PROTEIN HSP 90-ALPHA, 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamide (3 entities in total)
Functional Keywordsatpase, chaperone, atp-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight26265.37
Authors
Primary citation
Fogliatto, G.,Gianellini, L.M.,Brasca, M.G.,Casale, E.,Ballinari, D.,Ciomei, M.,Degrassi, A.,De Ponti, A.,Germani, M.,Guanci, M.,Paolucci, M.,Polucci, P.,Russo, M.,Sola, F.,Valsasina, B.,Visco, C.,Zuccotto, F.,Donati, D.,Felder, E.,Pesenti, E.,Mantegani, S.,Galvani, A.,Isacchi, A.
Nms-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity in Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases.
Clin.Cancer Res., 19:3520-, 2013
PubMed: 23674492 (PDB entries with the same primary citation)
DOI: 10.1158/1078-0432.CCR-12-3512
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.202201.6%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4b7p
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Molmil generated image of 4b7p
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Molmil generated image of 4b7p
rotated about y axis by 90°