2FWZ
Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71
Summary for 2FWZ
Entry DOI | 10.2210/pdb2fwz/pdb |
Related | 1UY6 1ZW9 2FWY |
Descriptor | Heat shock protein HSP 90-alpha, 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE (3 entities in total) |
Functional Keywords | hsp90, grp94, chaperone, purine, pu3, h64, h71 |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 29285.51 |
Authors | Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-02-03, release date: 2006-10-03, Last modification date: 2023-08-30) |
Primary citation | Immormino, R.M.,Kang, Y.,Chiosis, G.,Gewirth, D.T. Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors. J.Med.Chem., 49:4953-4960, 2006 Cited by PubMed: 16884307DOI: 10.1021/jm060297x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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