Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2FWZ

Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71

Summary for 2FWZ
Entry DOI10.2210/pdb2fwz/pdb
Related1UY6 1ZW9 2FWY
DescriptorHeat shock protein HSP 90-alpha, 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE (3 entities in total)
Functional Keywordshsp90, grp94, chaperone, purine, pu3, h64, h71
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight29285.51
Authors
Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-02-03, release date: 2006-10-03, Last modification date: 2023-08-30)
Primary citationImmormino, R.M.,Kang, Y.,Chiosis, G.,Gewirth, D.T.
Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
J.Med.Chem., 49:4953-4960, 2006
Cited by
PubMed: 16884307
DOI: 10.1021/jm060297x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon