2FWZ

Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Heat shock protein HSP 90-alpha	polymer	256	28773.1	1	GenBank (61656605) Pfam (PF13589) UniProt (by SIFTS) (P07900) In PDB	Homo sapiens (human)	HSP90 protein
2	A	8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE	non-polymer		512.4	1	Chemie (H71)
3		water	water		18.0	322	Chemie (HOH)

Sequence modifications

A: 1 - 236 (GenBank: 61656605)

PDB	External Database	Details
Met -19	-	cloning artifact
Gly -18	-	cloning artifact
Ser -17	-	cloning artifact
Ser -16	-	cloning artifact
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	cloning artifact
Ser -8	-	cloning artifact
Gly -7	-	cloning artifact
Leu -6	-	cloning artifact
Val -5	-	cloning artifact
Pro -4	-	cloning artifact
Arg -3	-	cloning artifact
Gly -2	-	cloning artifact
Ser -1	-	cloning artifact
His 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28773.1
Non-Polymers*	Number of molecules	1
	Total formula weight	512.4
All*	Total formula weight	29285.5

*Water molecules are not included.