4B7K

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-SER PEPTIDE (20-MER)

4B7K の概要

• エントリーDOI: 10.2210/pdb4b7k/pdb
• 関連するPDBエントリー: 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 4AI8 4B7E
• 分子名称: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, CONSENSUS ANKYRIN REPEAT DOMAIN-SER, ZINC ION, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-transcription, helix-loop-helix-beta, dsbh, facial triad, helix-beta, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Nucleus: Q9NWT6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43130.54

構造登録者

Chowdhury, R.,Ge, W.,Schofield, C.J. (登録日: 2012-08-20, 公開日: 2013-01-23, 最終更新日: 2023-12-20)

• 主引用文献: Yang, M.,Hardy, A.P.,Chowdhury, R.,Loik, N.D.,Scotti, J.S.,McCullagh, J.S.,Claridge, T.D.,McDonough, M.A.,Ge, W.,Schofield, C.J.; Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.; Angew. Chem. Int. Ed. Engl., 52:1700-1704, 2013; PubMed: 23296631; DOI: 10.1002/anie.201208046

実験手法

X-RAY DIFFRACTION (2.39 Å)