4B7K
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-SER PEPTIDE (20-MER)
Summary for 4B7K
Entry DOI | 10.2210/pdb4b7k/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 4AI8 4B7E |
Descriptor | HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, CONSENSUS ANKYRIN REPEAT DOMAIN-SER, ZINC ION, ... (6 entities in total) |
Functional Keywords | oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-transcription, helix-loop-helix-beta, dsbh, facial triad, helix-beta, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus: Q9NWT6 |
Total number of polymer chains | 2 |
Total formula weight | 43130.54 |
Authors | Chowdhury, R.,Ge, W.,Schofield, C.J. (deposition date: 2012-08-20, release date: 2013-01-23, Last modification date: 2023-12-20) |
Primary citation | Yang, M.,Hardy, A.P.,Chowdhury, R.,Loik, N.D.,Scotti, J.S.,McCullagh, J.S.,Claridge, T.D.,McDonough, M.A.,Ge, W.,Schofield, C.J. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angew. Chem. Int. Ed. Engl., 52:1700-1704, 2013 Cited by PubMed: 23296631DOI: 10.1002/anie.201208046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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