4AI8

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE

Summary for 4AI8

Related2WA4 2Y0I 2W0X 2CGN 2WA3 2CGO 2YDE 1IZ3 1H2M 1MZE 1MZF 2YC0 1YCI 1H2N 1H2K 2XUM 1H2L
DescriptorHYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, SULFATE ION, GLYCEROL, ... (6 entities in total)
Functional Keywordsoxidoreductase, dioxygenase, metal-binding, helix-loop-helix-beta, dsbh, facial triad, transcription and epigenetic regulation, ankyrin repeat domain, beta-hydroxylation, transcription activator/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight41592.73
Authors
King, O.N.F.,Chowdhury, R.,Rose, N.R.,McDonough, M.A.,Clifton, I.J.,Schofield, C.J.,Kawamura, A. (deposition date: 2012-02-08, release date: 2012-10-03, Last modification date: 2019-02-06)
Primary citation
Rose, N.R.,Woon, E.C.,Tumber, A.,Walport, L.J.,Chowdhury, R.,Li, X.S.,King, O.N.,Lejeune, C.,Ng, S.S.,Krojer, T.,Chan, M.C.,Rydzik, A.M.,Hopkinson, R.J.,Che, K.H.,Daniel, M.,Strain-Damerell, C.,Gileadi, C.,Kochan, G.,Leung, I.K.,Dunford, J.,Yeoh, K.K.,Ratcliffe, P.J.,Burgess-Brown, N.,von Delft, F.,Muller, S.,Marsden, B.,Brennan, P.E.,McDonough, M.A.,Oppermann, U.,Klose, R.J.,Schofield, C.J.,Kawamura, A.
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55:6639-6643, 2012
PubMed: 22724510 (PDB entries with the same primary citation)
DOI: 10.1021/jm300677j
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers25 0.3% 9.3% 8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ai8
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More Biological unit images

Molmil generated image of 4ai8
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Molmil generated image of 4ai8
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Molmil generated image of 4ai8
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4ai8.pdb1.gz [117.56 KB])