4AEN

HLA-DR1 with covalently linked CLIP106-120 in reversed orientation

Summary for 4AEN

• Entry DOI: 10.2210/pdb4aen/pdb
• Related: 1A6A 1AQD 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HXY 1ICF 1IIE 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1L3H 1LO5 1MUJ 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2G9H 2SEB 2XN9 4AH2
• Descriptor: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BETA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, ... (5 entities in total)
• Functional Keywords: immune system, self antigen, invariant chain, clip
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Cell membrane; Single-pass type II membrane protein (Potential): P04233
• Total number of polymer chains: 3
• Total formula weight: 48305.32

Authors

Schlundt, A.,Guenther, S.,Sticht, J.,Wieczorek, M.,Roske, Y.,Heinemann, U.,Freund, C. (deposition date: 2012-01-11, release date: 2012-08-01, Last modification date: 2023-12-20)

• Primary citation: Schlundt, A.,Gunther, S.,Sticht, J.,Wieczorek, M.,Roske, Y.,Heinemann, U.,Freund, C.; Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex.; J.Mol.Biol., 423:294-, 2012; PubMed: 22820093; DOI: 10.1016/J.JMB.2012.07.008

Experimental method

X-RAY DIFFRACTION (2.2 Å)