1A6A
THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3
Summary for 1A6A
| Entry DOI | 10.2210/pdb1a6a/pdb |
| Descriptor | HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DR-1 beta chain, HLA class II histocompatibility antigen, gamma chain, ... (5 entities in total) |
| Functional Keywords | mhc glycoprotein, complex (transmembrane-glycoprotein), complex (transmembrane-glycoprotein) complex, complex (transmembrane/glycoprotein) |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 44523.09 |
| Authors | Ghosh, P.,Amaya, M.,Mellins, E.,Wiley, D.C. (deposition date: 1998-02-22, release date: 1998-05-27, Last modification date: 2024-10-23) |
| Primary citation | Ghosh, P.,Amaya, M.,Mellins, E.,Wiley, D.C. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature, 378:457-462, 1995 Cited by PubMed Abstract: A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM. PubMed: 7477400DOI: 10.1038/378457a0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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