3ZXH
MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor
Summary for 3ZXH
Entry DOI | 10.2210/pdb3zxh/pdb |
Related | 1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2YIG 456C 830C |
Descriptor | COLLAGENASE 3, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | metallo-enzyme, carboxylate inhibitor, collagen degradation, extracellular matrix, hydrolase, metal-binding, metalloprotease |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 40258.44 |
Authors | Clark, K.L.,Kulathila, R. (deposition date: 2011-08-10, release date: 2011-10-19, Last modification date: 2024-05-08) |
Primary citation | Tommasi, R.A.,Weiler, S.,Mcquire, L.W.,Rogel, O.,Chambers, M.,Clark, K.L.,Doughty, J.,Fang, J.,Ganu, V.,Grob, J.,Goldberg, R.,Goldstein, R.,Lavoie, S.,Kulathila, R.,Macchia, W.,Melton, R.,Springer, C.,Walker, M.,Zhang, J.,Zhu, L.,Shultz, M. Potent and Selective 2-Naphthylsulfonamide Substituted Hydroxamic Acid Inhibitors of Matrix Metalloproteinase-13. Bioorg.Med.Chem.Lett., 21:6440-, 2011 Cited by PubMed: 21937229DOI: 10.1016/J.BMCL.2011.08.087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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