3ZXH
MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 300 |
| Chain | Residue |
| A | HIS222 |
| A | HIS226 |
| A | HIS232 |
| A | E41401 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS172 |
| A | ASP174 |
| A | HIS187 |
| A | HIS200 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 302 |
| Chain | Residue |
| A | GLY180 |
| A | SER182 |
| A | LEU184 |
| A | ASP202 |
| A | GLU205 |
| A | ASP179 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | ASP128 |
| A | ASP203 |
| A | GLU205 |
| A | HOH2036 |
| A | HOH2038 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP162 |
| A | ASN194 |
| A | GLY196 |
| A | ASP198 |
| A | HOH2104 |
| A | HOH2106 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | SER146 |
| A | THR149 |
| A | HOH2061 |
| A | HOH2063 |
| A | HOH2070 |
| A | HOH2073 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE E41 A 401 |
| Chain | Residue |
| A | LEU184 |
| A | LEU185 |
| A | ALA186 |
| A | HIS222 |
| A | GLU223 |
| A | HIS226 |
| A | HIS232 |
| A | PRO242 |
| A | ILE243 |
| A | TYR244 |
| A | ZN300 |
| A | HOH2142 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1273 |
| Chain | Residue |
| A | LEU239 |
| A | ILE243 |
| A | TYR244 |
| A | THR245 |
| A | THR247 |
| A | HOH2183 |
| A | HOH2184 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 300 |
| Chain | Residue |
| B | HIS222 |
| B | HIS226 |
| B | HIS232 |
| B | E41401 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS172 |
| B | ASP174 |
| B | HIS187 |
| B | HIS200 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 302 |
| Chain | Residue |
| B | ASP179 |
| B | GLY180 |
| B | SER182 |
| B | LEU184 |
| B | ASP202 |
| B | GLU205 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP128 |
| B | ASP203 |
| B | GLU205 |
| B | HOH2035 |
| B | HOH2036 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP162 |
| B | ASN194 |
| B | GLY196 |
| B | ASP198 |
| B | HOH2094 |
| B | HOH2095 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE E41 B 401 |
| Chain | Residue |
| B | LEU184 |
| B | LEU185 |
| B | ALA186 |
| B | HIS222 |
| B | GLU223 |
| B | HIS226 |
| B | HIS232 |
| B | PRO242 |
| B | ILE243 |
| B | TYR244 |
| B | ZN300 |
| B | GOL1273 |
| B | HOH2138 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1270 |
| Chain | Residue |
| A | ASP179 |
| A | GLY180 |
| A | PRO181 |
| B | GLU205 |
| B | THR206 |
| B | TYR214 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1271 |
| Chain | Residue |
| B | HOH2119 |
| A | HIS172 |
| B | GLY168 |
| B | ILE169 |
| B | GLU171 |
| B | HOH2107 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1272 |
| Chain | Residue |
| B | LEU218 |
| B | LEU239 |
| B | ILE243 |
| B | TYR244 |
| B | THR245 |
| B | HOH2173 |
| B | HOH2174 |
| B | HOH2178 |
| B | HOH2179 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1273 |
| Chain | Residue |
| B | GLY183 |
| B | TYR214 |
| B | ILE243 |
| B | TYR244 |
| B | E41401 |
| B | HOH2177 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL219-LEU228 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 140 |
| Details | Region: {"description":"Interaction with TIMP2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8969305","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8576151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
