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2YIG

MMP13 in complex with a novel selective non zinc binding inhibitor

Summary for 2YIG
Entry DOI10.2210/pdb2yig/pdb
Related1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 456C 830C
DescriptorCOLLAGENASE 3, 4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)-N-(PYRIDIN-4-YLMETHYL)BENZAMIDE, ZINC ION, ... (6 entities in total)
Functional Keywordshydrolase, collagenase 3, mmp-13, matrixmetalloprotease
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains2
Total formula weight39868.75
Authors
Gerhardt, S.,Hargreaves, D. (deposition date: 2011-05-13, release date: 2011-06-29, Last modification date: 2024-05-08)
Primary citationSavi, C.D.,Morley, A.D.,Ting, A.,Nash, I.,Karabelas, K.,Wood, C.M.,James, M.,Norris, S.J.,Karoutchi, G.,Rankine, N.,Hamlin, G.,Macfaul, P.A.,Ryan, D.,Baker, S.V.,Hargreaves, D.,Gerhardt, S.
Selective Non Zinc Binding Inhibitors of Mmp13.
Bioorg.Med.Chem.Lett., 21:4215-, 2011
Cited by
PubMed Abstract: Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.
PubMed: 21669521
DOI: 10.1016/J.BMCL.2011.05.075
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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