1EUB

SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COLLAGENASE-3 (MMP-13) COMPLEXED TO A POTENT NON-PEPTIDIC SULFONAMIDE INHIBITOR

Summary for 1EUB

• Entry DOI: 10.2210/pdb1eub/pdb
• Related: 456C 830C
• Descriptor: COLLAGENASE 3, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: alpha helix, beta sheet, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P45452
• Total number of polymer chains: 1
• Total formula weight: 19843.85

Authors

Zhang, X.,Gonnella, N.C.,Koehn, J.,Pathak, N.,Ganu, V.,Melton, R.,Parker, D.,Hu, S.I.,Nam, K.Y. (deposition date: 2000-04-14, release date: 2001-04-14, Last modification date: 2022-02-16)

• Primary citation: Zhang, X.,Gonnella, N.C.,Koehn, J.,Pathak, N.,Ganu, V.,Melton, R.,Parker, D.,Hu, S.I.,Nam, K.Y.; Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1.; J.Mol.Biol., 301:513-524, 2000; PubMed: 10926524; DOI: 10.1006/jmbi.2000.3988

Experimental method

SOLUTION NMR