456C

CRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID

Summary for 456C

Entry DOI	10.2210/pdb456c/pdb
Descriptor	MMP-13, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, matrix metalloprotease
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	2
Total formula weight	39011.71
Authors	Lovejoy, B.,Welch, A.,Carr, S.,Luong, C.,Broka, C.,Hendricks, R.T.,Campbell, J.,Walker, K.,Martin, R.,Van Wart, H.,Browner, M.F. (deposition date: 1998-08-06, release date: 1999-08-06, Last modification date: 2023-08-09)
Primary citation	Lovejoy, B.,Welch, A.R.,Carr, S.,Luong, C.,Broka, C.,Hendricks, R.T.,Campbell, J.A.,Walker, K.A.,Martin, R.,Van Wart, H.,Browner, M.F. Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors. Nat.Struct.Biol., 6:217-221, 1999 Cited by PubMed: 10074939 DOI: 10.1038/6657 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation