1ZTQ
Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033
Summary for 1ZTQ
Entry DOI | 10.2210/pdb1ztq/pdb |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mmps, metalloprotease, hydrolase, mmp-13, collagenase, zinc chelator, hydroxamate, hydrophobic s1', p1' group |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P45452 |
Total number of polymer chains | 4 |
Total formula weight | 77405.68 |
Authors | Wu, J.,Rush III, T.S.,Hotchandani, R.,Du, X.,Geck, M.,Collins, E.,Xu, Z.B.,Skotnicki, J.,Levin, J.I.,Lovering, F. (deposition date: 2005-05-27, release date: 2006-05-30, Last modification date: 2024-02-14) |
Primary citation | Wu, J.,Rush III, T.S.,Hotchandani, R.,Du, X.,Geck, M.,Collins, E.,Xu, Z.B.,Skotnicki, J.,Levin, J.I.,Lovering, F.E. Identification of potent and selective MMP-13 inhibitors Bioorg.Med.Chem.Lett., 15:4105-4109, 2005 Cited by PubMed: 16005220DOI: 10.1016/j.bmcl.2005.06.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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