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1ZTQ

Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033

Summary for 1ZTQ
Entry DOI10.2210/pdb1ztq/pdb
DescriptorCollagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmmps, metalloprotease, hydrolase, mmp-13, collagenase, zinc chelator, hydroxamate, hydrophobic s1', p1' group
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (Probable): P45452
Total number of polymer chains4
Total formula weight77405.68
Authors
Wu, J.,Rush III, T.S.,Hotchandani, R.,Du, X.,Geck, M.,Collins, E.,Xu, Z.B.,Skotnicki, J.,Levin, J.I.,Lovering, F. (deposition date: 2005-05-27, release date: 2006-05-30, Last modification date: 2024-02-14)
Primary citationWu, J.,Rush III, T.S.,Hotchandani, R.,Du, X.,Geck, M.,Collins, E.,Xu, Z.B.,Skotnicki, J.,Levin, J.I.,Lovering, F.E.
Identification of potent and selective MMP-13 inhibitors
Bioorg.Med.Chem.Lett., 15:4105-4109, 2005
Cited by
PubMed: 16005220
DOI: 10.1016/j.bmcl.2005.06.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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