Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZTQ

Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0031012	cellular_component	extracellular matrix
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0031012	cellular_component	extracellular matrix
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 550

Chain	Residue
A	HIS197
A	HIS201
A	HIS207
A	033601

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 551

Chain	Residue
A	HIS147
A	ASP149
A	HIS162
A	HIS175
A	HOH701

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 560

Chain	Residue
A	ASP154
A	GLY155
A	SER157
A	LEU159
A	ASP177
A	GLU180

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 561

Chain	Residue
A	ASP137
A	ASN169
A	GLY171
A	ASP173
A	HOH659

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 562

Chain	Residue
A	THR101
A	ASP103
A	ASP178
A	GLU180
A	HOH622

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 552

Chain	Residue
B	HIS197
B	HIS201
B	HIS207
B	033602

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 553

Chain	Residue
B	HIS147
B	ASP149
B	HIS162
B	HIS175

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 563

Chain	Residue
B	ASP154
B	GLY155
B	SER157
B	LEU159
B	ASP177
B	GLU180

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 564

Chain	Residue
B	ASP137
B	ASN169
B	GLY171
B	ASP173
B	HOH641
B	HOH720

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 565

Chain	Residue
B	ASP103
B	ASP178
B	GLU180
B	HOH618
C	HOH615

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 554

Chain	Residue
C	HIS197
C	HIS201
C	HIS207
C	033603

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 555

Chain	Residue
C	HIS147
C	ASP149
C	HIS162
C	HIS175

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 566

Chain	Residue
C	ASP154
C	GLY155
C	SER157
C	LEU159
C	ASP177
C	GLU180

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 567

Chain	Residue
C	ASP137
C	ASN169
C	GLY171
C	ASP173
C	HOH604

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 568

Chain	Residue
B	HOH717
C	ASP103
C	ASP178
C	GLU180
C	HOH731

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 556

Chain	Residue
D	HIS197
D	HIS201
D	HIS207
D	033604

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 557

Chain	Residue
D	HIS147
D	ASP149
D	HIS162
D	HIS175

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 569

Chain	Residue
D	ASP154
D	GLY155
D	SER157
D	LEU159
D	ASP177
D	GLU180

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 570

Chain	Residue
D	ASP137
D	ASN169
D	GLY171
D	ASP173
D	HOH711
D	HOH712

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 571

Chain	Residue
A	HOH656
D	ASP103
D	ASP178
D	GLU180

site_id	CC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE 033 A 601

Chain	Residue
A	LEU160
A	ALA161
A	LEU193
A	HIS197
A	GLU198
A	HIS201
A	HIS207
A	GLY212
A	ALA213
A	LEU214
A	PHE216
A	PRO217
A	ILE218
A	TYR219
A	THR220
A	THR222
A	PHE227
A	PRO230
A	ZN550
A	HOH626
A	HOH635
A	HOH717
A	LEU159

site_id	CC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 033 B 602

Chain	Residue
B	TYR151
B	LEU159
B	LEU160
B	ALA161
B	LEU193
B	HIS197
B	GLU198
B	HIS201
B	HIS207
B	GLY212
B	LEU214
B	PHE216
B	PRO217
B	ILE218
B	TYR219
B	THR220
B	ZN552
B	HOH682
B	HOH690

site_id	CC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 033 C 603

Chain	Residue
C	LEU159
C	LEU160
C	ALA161
C	LEU193
C	HIS197
C	GLU198
C	HIS201
C	HIS207
C	GLY212
C	LEU214
C	PHE216
C	PRO217
C	ILE218
C	TYR219
C	PRO230
C	ZN554

site_id	CC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 033 D 604

Chain	Residue
D	LEU159
D	LEU160
D	ALA161
D	LEU193
D	HIS197
D	GLU198
D	HIS201
D	HIS207
D	GLY212
D	LEU214
D	PHE216
D	PRO217
D	ILE218
D	TYR219
D	ZN556
D	HOH654
D	HOH683

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL

Chain	Residue	Details
A	VAL194-LEU203

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:23913860

Chain	Residue	Details
A	GLU198
B	GLU198
C	GLU198
D	GLU198

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269\|PubMed:10926524, ECO:0000269\|PubMed:10986126, ECO:0000269\|PubMed:15734645, ECO:0000269\|PubMed:15780611, ECO:0000269\|PubMed:17196980, ECO:0000269\|PubMed:17623656, ECO:0000269\|PubMed:19422229, ECO:0000269\|PubMed:20005097, ECO:0000269\|PubMed:20726512, ECO:0000269\|PubMed:22689580, ECO:0000269\|PubMed:23810497, ECO:0000269\|PubMed:23913860, ECO:0000269\|PubMed:8969305

Chain	Residue	Details
A	ASP103
A	ASP177
A	ASP178
A	GLU180
B	ASP103
B	ASP137
B	ASP154
B	GLY155
B	SER157
B	LEU159
B	ASN169
A	ASP137
B	GLY171
B	ASP173
B	ASP177
B	ASP178
B	GLU180
C	ASP103
C	ASP137
C	ASP154
C	GLY155
C	SER157
A	ASP154
C	LEU159
C	ASN169
C	GLY171
C	ASP173
C	ASP177
C	ASP178
C	GLU180
D	ASP103
D	ASP137
D	ASP154
A	GLY155
D	GLY155
D	SER157
D	LEU159
D	ASN169
D	GLY171
D	ASP173
D	ASP177
D	ASP178
D	GLU180
A	SER157
A	LEU159
A	ASN169
A	GLY171
A	ASP173

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:10926524, ECO:0000269\|PubMed:10986126, ECO:0000269\|PubMed:15734645, ECO:0000269\|PubMed:15780611, ECO:0000269\|PubMed:17196980, ECO:0000269\|PubMed:17623656, ECO:0000269\|PubMed:19422229, ECO:0000269\|PubMed:20005097, ECO:0000269\|PubMed:20726512, ECO:0000269\|PubMed:22689580, ECO:0000269\|PubMed:23810497, ECO:0000269\|PubMed:23913860

Chain	Residue	Details
A	HIS147
B	ASP149
B	HIS162
B	HIS175
B	HIS197
B	HIS201
B	HIS207
B	MET215
C	HIS147
C	ASP149
C	HIS162
A	ASP149
C	HIS175
C	HIS197
C	HIS201
C	HIS207
C	MET215
D	HIS147
D	ASP149
D	HIS162
D	HIS175
D	HIS197
A	HIS162
D	HIS201
D	HIS207
D	MET215
A	HIS175
A	HIS197
A	HIS201
A	HIS207
A	MET215
B	HIS147

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:8576151

Chain	Residue	Details
A	ASN92
B	ASN92
C	ASN92
D	ASN92

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN127
B	ASN127
C	ASN127
D	ASN127

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)