3T3Q

Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Pilocarpine

Summary for 3T3Q

Entry DOI	10.2210/pdb3t3q/pdb
Related	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 2PG5 2PG6 2PG7 3EBS 3T3R 3T3S 3T3Z
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one, ... (4 entities in total)
Functional Keywords	cyp2a6, cytochrome p450 2a6, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221953.27
Authors	DeVore, N.M.,Scott, E.E. (deposition date: 2011-07-25, release date: 2011-12-07, Last modification date: 2023-09-13)
Primary citation	DeVore, N.M.,Meneely, K.M.,Bart, A.G.,Stephens, E.S.,Battaile, K.P.,Scott, E.E. Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine. Febs J., 279:1621-1631, 2012 Cited by PubMed: 22051186 DOI: 10.1111/j.1742-4658.2011.08412.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation