3EBS

Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Phenacetin

Summary for 3EBS

Entry DOI	10.2210/pdb3ebs/pdb
Related	1z10 1z11 2fdu 2fdv 2fdw 2fdy 2p85 2pg5 2pg6 2pg7
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, N-(4-ethoxyphenyl)acetamide, ... (4 entities in total)
Functional Keywords	cyp2a6, p450 2a6, cyp2a13, p450 2a13, monooxygenase, oxidoreducatase, heme, endoplasmic reticulum, iron, membrane, metal-binding, microsome, phenacetin, oxidoreductase, polymorphism
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221657.89
Authors	DeVore, N.M.,Scott, E.E. (deposition date: 2008-08-28, release date: 2008-09-23, Last modification date: 2023-08-30)
Primary citation	DeVore, N.M.,Smith, B.D.,Urban, M.J.,Scott, E.E. Key residues controlling phenacetin metabolism by human cytochrome P4502A enzymes. Drug Metab.Dispos., 36:2582-2590, 2008 Cited by PubMed: 18779312 DOI: 10.1124/dmd.108.023770 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation