3EBS
Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Phenacetin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Cytochrome P450 2A6 | polymer | 476 | 54663.6 | 4 | UniProt (P11509) Pfam (PF00067) In PDB | Homo sapiens (Human) | CYPIIA6, Coumarin 7-hydroxylase, P450 IIA3, CYP2A3, P450(I) |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, D | N-(4-ethoxyphenyl)acetamide | non-polymer | 179.2 | 3 | Chemie (N4E) | |||
4 | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 29 - 494 (UniProt: P11509)
PDB | External Database | Details |
---|---|---|
Met 23 | - | expression tag |
Ala 24 | - | expression tag |
Lys 25 | - | expression tag |
Lys 26 | - | expression tag |
Thr 27 | - | expression tag |
Ser 28 | - | expression tag |
Ser 208 | Ile 208 | engineered mutation |
Phe 300 | Ile 300 | engineered mutation |
Ala 301 | Gly 301 | engineered mutation |
Gly 369 | Ser 369 | engineered mutation |
His 495 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 218654.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3003.6 | |
All* | Total formula weight | 221657.9 |