3SFX
Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and tipifarnib
Summary for 3SFX
Entry DOI | 10.2210/pdb3sfx/pdb |
Related | 3Q73 3Q75 3Q78 3Q79 3Q7A 3Q7F 3SFY |
Descriptor | Cryptococcus neoformans protein farnesyltransferase alpha subunit, Cryptococcus neoformans protein farnesyltransferase beta subunit, ZINC ION, ... (8 entities in total) |
Functional Keywords | prenyltransferase, protein farnesyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Cryptococcus neoformans More |
Total number of polymer chains | 2 |
Total formula weight | 99456.35 |
Authors | Hast, M.A.,Beese, L.S. (deposition date: 2011-06-14, release date: 2011-08-03, Last modification date: 2024-02-28) |
Primary citation | Hast, M.A.,Nichols, C.B.,Armstrong, S.M.,Kelly, S.M.,Hellinga, H.W.,Alspaugh, J.A.,Beese, L.S. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286:35149-35162, 2011 Cited by PubMed: 21816822DOI: 10.1074/jbc.M111.250506 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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