3SFY

Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and ethylenediamine inhibitor 2

Summary for 3SFY

Entry DOI	10.2210/pdb3sfy/pdb
Related	3Q73 3Q75 3Q78 3Q79 3Q7A 3Q7F 3SFX
Descriptor	Cryptococcus neoformans protein farnesyltransferase alpha subunit, Cryptococcus neoformans protein farnesyltransferase beta subunit, ZINC ION, ... (8 entities in total)
Functional Keywords	prenyltransferase, protein farnesyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Cryptococcus neoformans More
Total number of polymer chains	2
Total formula weight	99524.46
Authors	Hast, M.A.,Beese, L.S. (deposition date: 2011-06-14, release date: 2011-08-03, Last modification date: 2024-02-28)
Primary citation	Hast, M.A.,Nichols, C.B.,Armstrong, S.M.,Kelly, S.M.,Hellinga, H.W.,Alspaugh, J.A.,Beese, L.S. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem., 286:35149-35162, 2011 Cited by PubMed: 21816822 DOI: 10.1074/jbc.M111.250506 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation