3INQ

Crystal structure of BCL-XL in complex with W1191542

Summary for 3INQ

• Entry DOI: 10.2210/pdb3inq/pdb
• Related: 2P1L 2YXJ 3FDL 3IO8 3IO9
• Descriptor: Bcl-2-like protein 1, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: apoptosis, alternative splicing, membrane, mitochondrion, nucleus, transmembrane
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817
• Total number of polymer chains: 2
• Total formula weight: 38112.08

Authors

Fairlie, W.D.,Smith, B.J.,Colman, P.M.,Czabotar, P.E.,Lee, E.F. (deposition date: 2009-08-12, release date: 2009-09-01, Last modification date: 2023-11-01)

• Primary citation: Lee, E.F.,Czabotar, P.E.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D.; Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands; J. Biol. Chem., 284:30508-30517, 2009; PubMed: 19726685; DOI: 10.1074/jbc.M109.040725

Experimental method

X-RAY DIFFRACTION (2 Å)