2YJA

Stapled Peptides binding to Estrogen Receptor alpha.

Summary for 2YJA

Related2YAT 1XP1 1QKT 1R5K 1ZKY 2BJ4 1AKF 1HCP 1HCQ 1A52 1QKU 1G50 1XP6 1PCG 2B1V 2JF9 1UOM 1YIM 2AYR 3ERT 1YIN 1ERR 1X7R 3ERD 1L2I 1XP9 2FAI 1GWR 1SJ0 2JFA 1GWQ 1XPC 1X7E 1XQC 1ERE 2YJD 2LDD 2LDA 2LDC
DescriptorSTAPLED PEPTIDE, ESTROGEN RECEPTOR, ESTRADIOL, ... (4 entities in total)
Functional Keywordshormone receptor-peptide complex, hormone receptor/peptide
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 1: Nucleus. Isoform 3: Nucleus P03372
Total number of polymer chains2
Total molecular weight30780.33
Authors
Primary citation
Phillips, C.,Roberts, L.R.,Schade, M.,Bazin, R.,Bent, A.,Davies, N.L.,Moore, R.,Pannifer, A.D.,Pickford, A.R.,Prior, S.H.,Read, C.M.,Scott, A.,Brown, D.G.,Xu, B.,Irving, S.L.
Design and Structure of Stapled Peptides Binding to Estrogen Receptors.
J.Am.Chem.Soc., 133:9696-, 2011
PubMed: 21612236 (PDB entries with the same primary citation)
DOI: 10.1021/JA202946K
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24111.2%6.5%11.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2yja
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Molmil generated image of 2yja
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Molmil generated image of 2yja
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More Biological unit images

Molmil generated image of 2yja
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Molmil generated image of 2yja
rotated about x axis by 90°
Molmil generated image of 2yja
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2yja.pdb1.gz [89.25 KB])