2AYR

A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats

Summary for 2AYR

Entry DOI	10.2210/pdb2ayr/pdb
Descriptor	Estrogen receptor, 6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL (3 entities in total)
Functional Keywords	receptor, transcription, transcription regulation, ligand-binding, serm
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	28814.81
Authors	Hummel, C.W.,Geiser, A.G.,Bryant, H.U.,Cohen, I.R.,Dally, R.D.,Fong, K.C.,Frank, S.A.,Hinklin, R.,Jones, S.A.,Lewis, G.,McCann, D.J.,Shepherd, T.A.,Tian, H.,Rudman, D.G.,Wallace, O.B.,Wang, Y.,Dodge, J.A. (deposition date: 2005-09-07, release date: 2005-11-22, Last modification date: 2023-08-23)
Primary citation	Hummel, C.W.,Geiser, A.G.,Bryant, H.U.,Cohen, I.R.,Dally, R.D.,Fong, K.C.,Frank, S.A.,Hinklin, R.,Jones, S.A.,Lewis, G.,McCann, D.J.,Rudman, D.G.,Shepherd, T.A.,Tian, H.,Wallace, O.B.,Wang, Y.,Dodge, J.A. A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats J.Med.Chem., 48:6772-6775, 2005 Cited by PubMed: 16250633 DOI: 10.1021/jm050723z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation