1XQC
X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution
Summary for 1XQC
Entry DOI | 10.2210/pdb1xqc/pdb |
Related | 1UOM |
Descriptor | Estrogen receptor, (1S)-1-{4-[(9AR)-OCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-2-YL]PHENYL}-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL (3 entities in total) |
Functional Keywords | alpha-helical sandwich, nuclear hormone receptor, ligand binding domain, hormone receptor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 4 |
Total formula weight | 117646.45 |
Authors | Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Geiser, M.,Halleux, C.,Kallen, J.,Keller, H.J.,Ramage, P. (deposition date: 2004-10-12, release date: 2005-02-01, Last modification date: 2023-10-25) |
Primary citation | Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Geiser, M.,Halleux, C.,Kallen, J.,Keller, H.J.,Ramage, P. Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure-Activity Relationship of ERalpha-Selective Tetrahydroisoquinoline Ligands J.Med.Chem., 48:364-379, 2005 Cited by PubMed: 15658851DOI: 10.1021/jm040858p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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