1PCG
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
Summary for 1PCG
Entry DOI | 10.2210/pdb1pcg/pdb |
Descriptor | estrogen receptor, peptide inhibitor, ESTRADIOL, ... (4 entities in total) |
Functional Keywords | co-activator binding site, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 4 |
Total formula weight | 58362.82 |
Authors | Leduc, A.M.,Trent, J.O.,Wittliff, J.L.,Bramlett, K.S.,Briggs, S.L.,Chirgadze, N.Y.,Wang, Y.,Burris, T.P.,Spatola, A.F. (deposition date: 2003-05-16, release date: 2003-10-28, Last modification date: 2021-10-27) |
Primary citation | Leduc, A.M.,Trent, J.O.,Wittliff, J.L.,Bramlett, K.S.,Briggs, S.L.,Chirgadze, N.Y.,Wang, Y.,Burris, T.P.,Spatola, A.F. Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions Proc.Natl.Acad.Sci.USA, 100:11273-11278, 2003 Cited by PubMed: 13679575DOI: 10.1073/pnas.1934759100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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