1PCG
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | estrogen receptor | polymer | 244 | 27817.6 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D (E, F) | peptide inhibitor | polymer | 9 | 1091.4 | 2 | |||
| 3 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) PubChem (16757676) PubChem (1807201) PubChem (450) PubChem (5757) PubChem (5998) PubChem (10596) PubChem (14880) PubChem (68570) PubChem (177015577) PubChem (43912931) PubChem (44284023) PubChem (46781508) PubChem (667480) PubChem (667515) PubChem (721867) PubChem (1807200) PubChem (928284) PubChem (54403267) PubChem (56624791) PubChem (1258565) PubChem (57041922) PubChem (58650893) PubChem (59084698) PubChem (68014581) PubChem (68209947) PubChem (70220248) PubChem (5317221) PubChem (70864205) PubChem (5745505) PubChem (6328313) PubChem (6432565) PubChem (6560352) PubChem (6603846) PubChem (6918968) PubChem (6919041) PubChem (7000012) PubChem (7004689) PubChem (7048584) PubChem (7048670) PubChem (7061189) PubChem (7067800) PubChem (9795489) PubChem (9811784) PubChem (91740223) PubChem (9903595) PubChem (9938293) PubChem (11869602) PubChem (11870431) PubChem (12313787) PubChem (12313791) PubChem (12313794) PubChem (5317222) PubChem (101691329) PubChem (118548795) PubChem (12313788) PubChem (126969992) PubChem (129010410) PubChem (129317336) PubChem (130307439) PubChem (130307440) PubChem (162947701) PubChem (166849971) PubChem (143489158) PubChem (144605119) PubChem (145157829) PubChem (145610824) PubChem (154109755) PubChem (172873304) | |||
| 4 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 304 - 547 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57818.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.8 | |
| All* | Total formula weight | 58362.8 |
