1PCG
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | estrogen receptor | polymer | 244 | 27817.6 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D (E, F) | peptide inhibitor | polymer | 9 | 1091.4 | 2 | |||
| 3 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
| 4 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 304 - 547 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57818.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.8 | |
| All* | Total formula weight | 58362.8 |
