2XZD

Caspase-3 in Complex with an Inhibitory DARPin-3.4

Summary for 2XZD

• Entry DOI: 10.2210/pdb2xzd/pdb
• Related: 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP
• Descriptor: CASPASE-3, DARPIN-3.4, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (6 entities in total)
• Functional Keywords: hydrolase-protein binding complex, de novo protein, apoptosis, ankyrin repeat protein, ribosome display, hydrolase/protein binding
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P42574 2XZD
• Total number of polymer chains: 6
• Total formula weight: 91367.56

Authors

Barandun, J.,Schroeder, T.,Mittl, P.,Grutter, M.G. (deposition date: 2010-11-24, release date: 2011-12-14, Last modification date: 2023-12-20)

• Primary citation: Schroeder, T.,Barandun, J.,Flutsch, A.,Briand, C.,Mittl, P.,Grutter, M.G.; Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.; Structure, 21:277-, 2013; PubMed: 23333429; DOI: 10.1016/J.STR.2012.12.011

Experimental method

X-RAY DIFFRACTION (2.1 Å)