2XZD

Caspase-3 in Complex with an Inhibitory DARPin-3.4

Summary for 2XZD

Related1RHK 1RHQ 2DKO 2XYP 2CJY 2J31 2XYH 2CJX 1RE1 2XYG 2C1E 2CNO 1GFW 1QX3 1RHM 1NME 2J33 1RHR 1NMS 1NMQ 1RHJ 2CNN 2C2K 2CNL 2C2M 1CP3 2CNK 2J30 1PAU 2CDR 2J32 1I3O 1RHU 2C2O
DescriptorCASPASE-3, DARPIN-3.4, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (6 entities in total)
Functional Keywordshydrolase-protein binding complex, de novo protein, apoptosis, ankyrin repeat protein, ribosome display, hydrolase/protein binding
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCytoplasm P42574 2XZD
Total number of polymer chains6
Total molecular weight91367.56
Authors
Barandun, J.,Schroeder, T.,Mittl, P.,Grutter, M.G. (deposition date: 2010-11-24, release date: 2011-12-14, Last modification date: 2013-02-20)
Primary citation
Schroeder, T.,Barandun, J.,Flutsch, A.,Briand, C.,Mittl, P.,Grutter, M.G.
Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21:277-, 2013
PubMed: 23333429 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2012.12.011
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.234501.7%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2xzd
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Molmil generated image of 2xzd
rotated about x axis by 90°
Molmil generated image of 2xzd
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2xzd
no rotation
Molmil generated image of 2xzd
rotated about x axis by 90°
Molmil generated image of 2xzd
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2xzd.pdb2.gz [123.64 KB])
Coordinate files for Biological unit (2xzd.pdb1.gz [123.5 KB])