2XZD
Caspase-3 in Complex with an Inhibitory DARPin-3.4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | CASPASE-3 | polymer | 149 | 16874.2 | 2 | UniProt (P42574) Pfam (PF00656) In PDB | HOMO SAPIENS (HUMAN) | CASP-3, APOPAIN, CYSTEINE PROTEASE CPP32, CPP-32 PROTEIN YAM, SREBP CLEAVAGE ACTIVITY 1, SCA-1 |
2 | B, D | CASPASE-3 | polymer | 118 | 13832.7 | 2 | UniProt (P42574) Pfam (PF00656) In PDB | HOMO SAPIENS (HUMAN) | CASP-3, APOPAIN, CYSTEINE PROTEASE CPP32, CPP-32 PROTEIN YAM, SREBP CLEAVAGE ACTIVITY 1, SCA-1 |
3 | G, H | DARPIN-3.4 | polymer | 136 | 14740.5 | 2 | SYNTHETIC CONSTRUCT | ||
4 | A, C | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 3 | Chemie (MRD) | |||
5 | B | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
6 | water | water | 18.0 | 317 | Chemie (HOH) |
Sequence modifications
A, C: 27 - 175 (UniProt: P42574)
B, D: 176 - 277 (UniProt: P42574)
PDB | External Database | Details |
---|---|---|
Ser 28 | Asp 28 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 278 | - | expression tag |
Leu 279 | - | expression tag |
Glu 280 | - | expression tag |
Val 281 | - | expression tag |
Leu 282 | - | expression tag |
Phe 283 | - | expression tag |
Gln 284 | - | expression tag |
Gly 285 | - | expression tag |
Pro 286 | - | expression tag |
His 287 | - | expression tag |
His 288 | - | expression tag |
His 289 | - | expression tag |
His 290 | - | expression tag |
His 291 | - | expression tag |
His 292 | - | expression tag |
His 293 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 90894.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 472.7 | |
All* | Total formula weight | 91367.6 |