2CNK

Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.

Summary for 2CNK

• Entry DOI: 10.2210/pdb2cnk/pdb
• Related: 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNL 2CNN 2CNO
• Related PRD ID: PRD_000673
• Descriptor: CASPASE-3 P17 SUBUNIT, CASPASE-3 P12 SUBUNIT, AZA-PEPTIDE EXPOXIDE, ... (4 entities in total)
• Functional Keywords: thiol protease, phosphorylation, cysteine-protease, complex (protease-inhibitor), protease, epoxides, tetramer, apoptosis, hydrolase, aza-peptide, epoxysuccinyl, ice, yama, cpp32, clan cd, aza-asp, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 3
• Total formula weight: 29413.77

Authors

Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G. (deposition date: 2006-05-22, release date: 2007-05-22, Last modification date: 2023-11-15)

• Primary citation: Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G.; Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors; Biochemistry, 45:9059-, 2006; PubMed: 16866351; DOI: 10.1021/BI060364P

Experimental method

X-RAY DIFFRACTION (1.75 Å)