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2C2M

Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.

Summary for 2C2M
Entry DOI10.2210/pdb2c2m/pdb
Related1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2J30 2J31 2J32 2J33
Related PRD IDPRD_000770
DescriptorCASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12, AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-14-[4-(BENZYLOXY)-4-OXOBUTANOYL]-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14 -PENTAAZAHEXADECAN-16-OIC ACID, ... (4 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, apoptosis, cysteine-protease, ice, thiol protease, zymogen, cpp32, yama, aza-peptide, michael acceptor, aza-asp, clan cd, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCytoplasm: P42574 P42574
Total number of polymer chains3
Total formula weight29397.77
Authors
Ganesan, R.,Jelakovic, S.,Ekici, O.D.,Li, Z.Z.,James, K.E.,Asgian, J.L.,Campbell, A.,Mikolajczyk, J.,Salvesen, G.S.,Gruetter, M.G.,Powers, J.C. (deposition date: 2005-09-29, release date: 2006-09-20, Last modification date: 2023-11-15)
Primary citationEkici, O.D.,Li, Z.Z.,Campbell, A.J.,James, K.E.,Asgian, J.L.,Mikolajczyk, J.,Salvesen, G.S.,Ganesan, R.,Jelakovic, S.,Grutter, M.G.,Powers, J.C.
Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49:5728-, 2006
Cited by
PubMed: 16970398
DOI: 10.1021/JM0601405
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.94 Å)
Structure validation

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