1RE1

CRYSTAL STRUCTURE OF CASPASE-3 WITH A NICOTINIC ACID ALDEHYDE INHIBITOR

Summary for 1RE1

• Entry DOI: 10.2210/pdb1re1/pdb
• Related: 1pau
• Descriptor: Caspase-3, (3S)-3-{[(5-BROMOPYRIDIN-3-YL)CARBONYL]AMINO}-4-OXOBUTANOIC ACID, ... (4 entities in total)
• Functional Keywords: cysteine protease, caspase-3, apopain, cpp32, yama, complex (protease-inhibitor), hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 2
• Total formula weight: 28851.60

Authors

Becker, J.W.,Rotonda, J.,Soisson, S.M. (deposition date: 2003-11-06, release date: 2004-05-11, Last modification date: 2023-09-20)

• Primary citation: Becker, J.W.,Rotonda, J.,Soisson, S.M.,Aspiotis, R.,Bayly, C.,Francoeur, S.,Gallant, M.,Garcia-Calvo, M.,Giroux, A.,Grimm, E.,Han, Y.,Mckay, D.,Nicholson, D.W.,Peterson, E.,Renaud, J.,Roy, S.,Thornberry, N.,Zamboni, R.; Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis; J.Med.Chem., 47:2466-2474, 2004; PubMed: 15115390; DOI: 10.1021/jm0305523

Experimental method

X-RAY DIFFRACTION (2.5 Å)