1NMS

Caspase-3 tethered to irreversible inhibitor

Summary for 1NMS

Entry DOI	10.2210/pdb1nms/pdb
Related	1NME 1NMQ
Descriptor	Caspase-3, 5-[4-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-BENZYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID (3 entities in total)
Functional Keywords	caspase-3, tether, irreversible, inhibitor, apoptosis, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42574
Total number of polymer chains	2
Total formula weight	57965.89
Authors	Erlanson, D.A.,Lam, J.,Wiesmann, C.,Luong, T.N.,Simmons, R.L.,DeLano, W.L.,Choong, I.C.,Flanagan, W.M.,Lee, D.,O'Brian, T. (deposition date: 2003-01-10, release date: 2003-03-11, Last modification date: 2023-08-16)
Primary citation	Erlanson, D.A.,Lam, J.W.,Wiesmann, C.,Luong, T.N.,Simmons, R.L.,DeLano, W.L.,Choong, I.C.,Burdett, M.T.,Flanagan, W.M.,Lee, D.,Gordon, E.M.,O'Brien, T. In situ assembly of enzyme inhibitors using extended tethering. Nat.Biotechnol., 21:308-314, 2003 Cited by PubMed: 12563278 DOI: 10.1038/nbt786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation