2XWJ

Crystal Structure of Complement C3b in Complex with Factor B

Summary for 2XWJ

Related1DLE 1RRK 2XQW 1RS0 2WII 2XWB 2A74 1GHQ 2HR0 2WIN 2A73 1Q0P 2WY7 1W2S 1C3D 1RTK 2WY8 2XW9 2XWA
DescriptorCOMPLEMENT C3 BETA CHAIN, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT FACTOR B, ... (6 entities in total)
Functional Keywordsimmune system, pro-convertase, hydrolase, serine protease, conformational changes, alternative pathway
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01024 P01024 P00751
Total number of polymer chains12
Total molecular weight1036653.74
Authors
Forneris, F.,Ricklin, D.,Wu, J.,Tzekou, A.,Wallace, R.S.,Lambris, J.D.,Gros, P. (deposition date: 2010-11-04, release date: 2011-01-12, Last modification date: 2012-04-11)
Primary citation
Forneris, F.,Ricklin, D.,Wu, J.,Tzekou, A.,Wallace, R.S.,Lambris, J.D.,Gros, P.
Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330:1816-, 2010
PubMed: 21205667 (PDB entries with the same primary citation)
DOI: 10.1126/SCIENCE.1195821
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.279111.3%0.9%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution