2XWJ
Crystal Structure of Complement C3b in Complex with Factor B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | COMPLEMENT C3 BETA CHAIN | polymer | 645 | 71393.3 | 4 | UniProt (P01024) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) | HOMO SAPIENS (HUMAN) | |
| 2 | B, D, F, H (B, D, F, H) | COMPLEMENT C3 ALPHA CHAIN | polymer | 915 | 104074.1 | 4 | UniProt (P01024) Pfam (PF07677) Pfam (PF01759) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) | HOMO SAPIENS (HUMAN) | |
| 3 | I, J, K, L (I, J, K, L) | COMPLEMENT FACTOR B | polymer | 741 | 83194.9 | 4 | UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | C3/C5 CONVERTASE, GLYCINE-RICH BETA GLYCOPROTEIN, GBG, PBF2, PROPERDIN FACTOR B |
| 4 | M, N, O, P, Q... (B, D, F, H, I...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 5 | R, T, V, X (I, J, K, L) | NICKEL (II) ION | non-polymer | 58.7 | 4 | Chemie (NI) | |||
| 6 | AA, BA, CA, Y, Z (K, L, I, J) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 727 - 1641 (UniProt: P01024)
I, J, K, L: 1 - 739 (UniProt: P00751)
| PDB | External Database | Details |
|---|---|---|
| Glu 991 | Gln 1013 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 740 | - | expression tag |
| Ala 741 | - | expression tag |
| Gly 254 | Asp 279 | engineered mutation |
| Asp 260 | Asn 285 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 1034649.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2004.4 | |
| All* | Total formula weight | 1036653.7 |
