2XNE

Structure of Aurora-A bound to an imidazopyrazine inhibitor

Summary for 2XNE

Entry DOI	10.2210/pdb2xne/pdb
Related	1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNG
Descriptor	SERINE/THREONINE-PROTEIN KINASE 6, 3-chloro-N-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine (3 entities in total)
Functional Keywords	ser-thr protein kinase complex, proto-oncogene, kinase, mitosis, cell cycle, microtubule, transferase, cytoskeleton, cell division
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	32033.24
Authors	Kosmopoulou, M.,Bayliss, R. (deposition date: 2010-08-02, release date: 2010-09-22, Last modification date: 2023-12-20)
Primary citation	Bouloc, N.,Large, J.M.,Kosmopoulou, M.,Sun, C.,Faisal, A.,Matteucci, M.,Reynisson, J.,Brown, N.,Atrash, B.,Blagg, J.,McDonald, E.,Linardopoulos, S.,Bayliss, R.,Bavetsias, V. Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg. Med. Chem. Lett., 20:5988-5993, 2010 Cited by PubMed: 20833547 DOI: 10.1016/j.bmcl.2010.08.091 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation