2XNE
Structure of Aurora-A bound to an imidazopyrazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE 6 | polymer | 272 | 31626.4 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA KINASE A, SERINE/THREONINE-PROTEIN KINASE AURORA-A, SERINE/THREONINE-PROTEIN KINASE 15, AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-RELATED KINASE 1, ARK-1, HARK1 |
| 2 | B (A) | 3-chloro-N-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine | non-polymer | 406.9 | 1 | Chemie (ASH) | |||
| 3 | C (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 122 - 392 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 121 | - | expression tag |
| Asn 274 | Asp 274 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31626.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 406.9 | |
| All* | Total formula weight | 32033.2 |
