2XC4

Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor

2XC4 の概要

• エントリーDOI: 10.2210/pdb2xc4/pdb
• 関連するPDBエントリー: 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1KYE 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2FZZ 2G00 2GD4 2J2U 2J34 2J38 2J4I 2J94 2J95 2JKH 2UWL 2UWO 2UWP 2VH0 2VH6 2VVC 2VVU 2VVV 2VWL 2VWM 2VWN 2VWO 2W26 2W3I 2W3K 2WYG 2WYJ 2XBV 2XBW 2XBX 2XBY 2XC0 2XC5
• 分子名称: ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: blood clotting, coagulation factor, egf-like domain, gamma-carboxyglutamic acid, hydrolase, hydroxylation, zymogen
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33861.85

構造登録者

Banner, D.W.,Benz, J.,Schlatter, D.,Thomi, S.,Haap, W. (登録日: 2010-04-16, 公開日: 2010-08-04, 最終更新日: 2024-05-01)

主引用文献

Anselm, L.,Banner, D.W.,Benz, J.,Groebke Zbinden, K.,Himber, J.,Hilpert, H.,Huber, W.,Kuhn, B.,Mary, J.L.,Otteneder, M.B.,Panday, N.,Ricklin, F.,Stahl, M.,Thomi, S.,Haap, W.
Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20:5313-, 2010

PubMed Abstract: A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663, exhibits excellent selectivity against a panel of serine proteases and good pharmacokinetic properties in rats and monkeys. A Phase I clinical study with R1663 has been finalized.

PubMed: 20650636
DOI: 10.1016/J.BMCL.2010.06.126

実験手法

X-RAY DIFFRACTION (1.67 Å)