1KSN

Crystal Structure of Human Coagulation Factor XA Complexed with FXV673

Summary for 1KSN

Entry DOI	10.2210/pdb1ksn/pdb
Related	1EZQ 1F0R 1F0S 1F0T 1F0U
Descriptor	COAGULATION FACTOR XA, CALCIUM ION, METHYL-3-(4'-N-OXOPYRIDYLPHENOYL)-3-METHYL-2-(M-AMIDINOBENZYL)-PROPIONATE, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00742 P00742
Total number of polymer chains	2
Total formula weight	44248.97
Authors	Maignan, S.,Guilloteau, J.P. (deposition date: 2002-01-14, release date: 2002-06-19, Last modification date: 2011-07-13)
Primary citation	Guertin, K.R.,Gardner, C.J.,Klein, S.I.,Zulli, A.L.,Czekaj, M.,Gong, Y.,Spada, A.P.,Cheney, D.L.,Maignan, S.,Guilloteau, J.P.,Brown, K.D.,Colussi, D.J.,Chu, V.,Heran, C.L.,Morgan, S.R.,Bentley, R.G.,Dunwiddie, C.T.,Leadley, R.J.,Pauls, H.W. Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity. Bioorg.Med.Chem.Lett., 12:1671-1674, 2002 Cited by PubMed: 12039587 DOI: 10.1016/S0960-894X(02)00213-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation