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1Z6E

Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)

Summary for 1Z6E
Entry DOI10.2210/pdb1z6e/pdb
DescriptorCoagulation factor X, 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-N-(4-{2-[(DIMETHYLAMINO)METHYL]-1H-IMIDAZOL-1-YL}-2-FLUOROPHENYL)-3-(TRIFLUOROMETHYL) -1H-PYRAZOLE-5-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsglycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, blood coagulation, cleavage on pair of basic residues, disulfide bond, egf-like domain
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P00742 P00742
Total number of polymer chains2
Total formula weight32564.80
Authors
Alexander, R.S. (deposition date: 2005-03-22, release date: 2006-03-28, Last modification date: 2023-08-23)
Primary citationQuan, M.L.,Lam, P.Y.S.,Han, Q.,Pinto, D.J.P.,He, M.Y.,Li, R.,Ellis, C.D.,Clark, C.G.,Teleha, C.A.,Sun, J.-H.,Alexander, R.S.,Bai, S.,Luettgen, J.M.,Knabb, R.M.,Wong, P.C.,Wexler, R.R.
Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.
J.Med.Chem., 48:1729-1744, 2005
Cited by
PubMed: 15771420
DOI: 10.1021/jm0497949
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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