1LPG

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79.

Summary for 1LPG

Related1LPK 1LPZ 1LQD 1LQE
DescriptorBlood coagulation factor Xa, CALCIUM ION, [4-({[5-BENZYLOXY-1-(3-CARBAMIMIDOYL-BENZYL)-1H-INDOLE-2-CARBONYL]-AMINO}-METHYL)-PHENYL]-TRIMETHYL-AMMONIUM, ... (5 entities in total)
Functional Keywordsprotein inhibitor complex, blood coagulation factor, serine proteinase, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted P00742 P00742
Total number of polymer chains2
Total molecular weight44348.15
Authors
Schreuder, H.A.,Brachvogel, V.,Liesum, A. (deposition date: 2002-05-08, release date: 2003-05-08, Last modification date: 2011-07-13)
Primary citation
Matter, H.,Defossa, E.,Heinelt, U.,Blohm, P.M.,Schneider, D.,Mueller, A.,Herok, S.,Schreuder, H.,Liesum, A.,Brachvogel, B.,Loenze, P.,Walser, A.,Al-Obeidi, F.,Wildgoose, P.
Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
J.Med.Chem., 45:2749-2769, 2002
PubMed: 12061878 (PDB entries with the same primary citation)
DOI: 10.1021/jm0111346
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2651007.4%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution