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2XAG

Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine

Summary for 2XAG
Entry DOI10.2210/pdb2xag/pdb
Related2COM 2H94 2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAH 2XAJ 2XAQ 2XAS
DescriptorLYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywordsamine oxidase, chromatin regulator, histone inhibitor binding, methylation, nucleosome core, oxidoreductase, oxidoreductase-repressor complex, chromatin remodelling, transcription
Biological sourceHOMO SAPIENS
More
Cellular locationNucleus: O60341 Q9UKL0
Total number of polymer chains2
Total formula weight147127.05
Authors
Primary citationBinda, C.,Valente, S.,Romanenghi, M.,Pilotto, S.,Cirilli, R.,Karytinos, A.,Ciossani, G.,Botrugno, O.A.,Forneris, F.,Tardugno, M.,Edmondson, D.E.,Minucci, S.,Mattevi, A.,Mai, A.
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132:6827-, 2010
Cited by
PubMed: 20415477
DOI: 10.1021/JA101557K
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

217705

건을2024-03-27부터공개중

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