2X7E

Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol

Summary for 2X7E

Related1II6 2FKY 2UYI 1Q0B 2WOG 2X2R 2G1Q 2UYM 1YRS 2FL6 2GM1 1X88 2FL2 2X7C 2X7D
DescriptorKINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsmicrotubule, atp-binding, motor protein, cell division, mitosis, inhibitor, cell cycle, nucleotide-binding, ksp
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P52732
Total number of polymer chains2
Total molecular weight83767.02
Authors
Kaan, H.Y.K.,Ulaganathan, V.,Rath, O.,Laggner, C.,Prokopcova, H.,Dallinger, D.,Kappe, C.O.,Kozielski, F. (deposition date: 2010-02-26, release date: 2010-07-14, Last modification date: 2011-09-21)
Primary citation
Kaan, H.Y.K.,Ulaganathan, V.,Rath, O.,Prokopcova, H.,Dallinger, D.,Kappe, C.O.,Kozielski, F.
Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53:5676-, 2010
PubMed: 20597485 (PDB entries with the same primary citation)
DOI: 10.1021/JM100421N
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.270130.8%6.9%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution