2GM1
Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide
Summary for 2GM1
Entry DOI | 10.2210/pdb2gm1/pdb |
Descriptor | KINESIN-RELATED MOTOR PROTEIN EG5, MAGNESIUM ION, N-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE, ... (5 entities in total) |
Functional Keywords | eg5 mg-adp complex inhibitor, cell cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P52732 |
Total number of polymer chains | 4 |
Total formula weight | 168141.66 |
Authors | Sheriff, S. (deposition date: 2006-04-05, release date: 2006-06-27, Last modification date: 2024-04-03) |
Primary citation | Kim, K.S.,Lu, S.,Cornelius, L.A.,Lombardo, L.J.,Borzilleri, R.M.,Schroeder, G.M.,Sheng, C.,Rovnyak, G.,Crews, D.,Schmidt, R.J.,Williams, D.K.,Bhide, R.S.,Traeger, S.C.,McDonnell, P.A.,Mueller, L.,Sheriff, S.,Newitt, J.A.,Pudzianowski, A.T.,Yang, Z.,Wild, R.,Lee, F.Y.,Batorsky, R.,Ryder, J.S.,Ortega-Nanos, M.,Shen, H.,Gottardis, M.,Roussell, D.L. Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors. Bioorg.Med.Chem.Lett., 16:3937-3942, 2006 Cited by PubMed: 16730979DOI: 10.1016/j.bmcl.2006.05.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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