2UYM

Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 37

Summary for 2UYM

Entry DOI	10.2210/pdb2uym/pdb
Related	1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI
Descriptor	KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kinesin spindle protein, ksp, eg5, complex, inhibitor, thiophene, atp-binding, cell cycle, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphorylation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: P52732
Total number of polymer chains	2
Total formula weight	83795.30
Authors	Lee, T.T. (deposition date: 2007-04-10, release date: 2007-05-22, Last modification date: 2023-12-13)
Primary citation	Pinkerton, A.B.,Lee, T.T.,Hoffman, T.Z.,Wang, Y.,Kahraman, M.,Cook, T.G.,Severance, D.,Gahman, T.C.,Noble, S.A.,Shiau, A.K.,Davis, R.L. Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors. Bioorg.Med.Chem.Lett., 17:3562-, 2007 Cited by PubMed: 17498954 DOI: 10.1016/J.BMCL.2007.04.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation