2X2R

Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid

Summary for 2X2R

Related1II6 2FKY 2UYI 1Q0B 2WOG 2G1Q 2UYM 2FL6 2GM1 1YRS 1X88 2FL2
DescriptorKINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ... (5 entities in total)
Functional Keywordsmitosis, cell cycle, microtubule, atp-binding, motor protein, cell division
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P52732
Total number of polymer chains3
Total molecular weight125551.71
Authors
Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F. (deposition date: 2010-01-15, release date: 2011-01-26, Last modification date: 2011-07-13)
Primary citation
Kaan, H.Y.K.,Weiss, J.,Menger, D.,Ulaganathan, V.,Tkocz, K.,Laggner, C.,Popowycz, F.,Joseph, B.,Kozielski, F.
Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54:1576-, 2011
PubMed: 21344920 (PDB entries with the same primary citation)
DOI: 10.1021/JM100991M
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.209110.3%5.6%8.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution