2WO8

MMP12 complex with a beta hydroxy carboxylic acid

2WO8 の概要

• エントリーDOI: 10.2210/pdb2wo8/pdb
• 関連するPDBエントリー: 1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2W0D 2WO9 2WOA
• 分子名称: MACROPHAGE METALLOELASTASE, ZINC ION, CALCIUM ION, ... (8 entities in total)
• 機能のキーワード: hydrolase, polymorphism, glycoprotein, metal-binding, matrix metalloprotease mmp-12 complex structure, metalloprotease, extracellular matrix, zymogen, protease, secreted
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P39900
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75681.32

構造登録者

Holmes, I.P.,Gaines, S.,Watson, S.P.,Lorthioir, O.,Walker, A.,Baddeley, S.J.,Herbert, S.,Egan, D.,Convery, M.A.,Singh, O.M.P.,Gross, J.W.,Strelow, J.M.,Smith, R.H.,Amour, A.J.,Brown, D.,Martin, S.L. (登録日: 2009-07-22, 公開日: 2009-09-08, 最終更新日: 2011-07-13)

• 主引用文献: Holmes, I.P.,Gaines, S.,Watson, S.P.,Lorthioir, O.,Walker, A.,Baddeley, S.J.,Herbert, S.,Egan, D.,Convery, M.A.,Singh, O.M.P.,Gross, J.W.,Strelow, J.M.,Smith, R.H.,Amour, A.J.,Brown, D.,Martin, S.L.; The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors.; Bioorg.Med.Chem.Lett., 19:5760-, 2009; PubMed: 19703773; DOI: 10.1016/J.BMCL.2009.07.155

実験手法

X-RAY DIFFRACTION (2 Å)