Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
D | 0004222 | molecular_function | metalloendopeptidase activity |
D | 0006508 | biological_process | proteolysis |
D | 0008237 | molecular_function | metallopeptidase activity |
D | 0008270 | molecular_function | zinc ion binding |
D | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 023 B 1268 |
Chain | Residue |
A | GLN259 |
B | GLU219 |
B | HIS222 |
B | HIS228 |
B | VAL235 |
B | PRO238 |
B | THR239 |
B | TYR240 |
B | LYS241 |
B | ZN1269 |
B | HOH2167 |
A | SER260 |
D | SER207 |
D | GOL1272 |
B | GLY179 |
B | ILE180 |
B | LEU181 |
B | ALA182 |
B | LEU214 |
B | THR215 |
B | HIS218 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 023 D 1266 |
Chain | Residue |
C | GLN259 |
C | SER260 |
D | GLY179 |
D | ILE180 |
D | LEU181 |
D | ALA182 |
D | THR215 |
D | HIS218 |
D | GLU219 |
D | HIS222 |
D | HIS228 |
D | PRO238 |
D | THR239 |
D | TYR240 |
D | LYS241 |
D | ZN1267 |
D | GOL1271 |
D | HOH2105 |
D | HOH2106 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1268 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
A | 0771271 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1269 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1270 |
Chain | Residue |
A | ASP175 |
A | GLY176 |
A | GLY178 |
A | ILE180 |
A | ASP198 |
A | GLU201 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 1269 |
Chain | Residue |
B | HIS218 |
B | HIS222 |
B | HIS228 |
B | 0231268 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 1270 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 1271 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | ILE180 |
B | ASP198 |
B | GLU201 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 1272 |
Chain | Residue |
B | ASP158 |
B | GLY190 |
B | GLY192 |
B | ASP194 |
B | HOH2060 |
B | HOH2086 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 1268 |
Chain | Residue |
C | HIS218 |
C | HIS222 |
C | HIS228 |
C | 0771271 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 1269 |
Chain | Residue |
C | HIS168 |
C | ASP170 |
C | HIS183 |
C | HIS196 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 1270 |
Chain | Residue |
C | ASP175 |
C | GLY176 |
C | GLY178 |
C | ILE180 |
C | ASP198 |
C | GLU201 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 1267 |
Chain | Residue |
D | HIS218 |
D | HIS222 |
D | HIS228 |
D | 0231266 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 1268 |
Chain | Residue |
D | HIS168 |
D | ASP170 |
D | HIS183 |
D | HIS196 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 1269 |
Chain | Residue |
D | ILE180 |
D | ASP198 |
D | GLU201 |
D | ASP175 |
D | GLY176 |
D | GLY178 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA D 1270 |
Chain | Residue |
D | ASP124 |
D | GLU199 |
D | GLU201 |
D | HOH2070 |
D | HOH2153 |
site_id | BC8 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 077 A 1271 |
Chain | Residue |
A | ILE180 |
A | LEU181 |
A | ALA182 |
A | HIS218 |
A | GLU219 |
A | HIS222 |
A | HIS228 |
A | ALA234 |
A | VAL235 |
A | PHE237 |
A | THR239 |
A | TYR240 |
A | LYS241 |
A | ZN1268 |
A | HOH2129 |
A | HOH2130 |
site_id | BC9 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 077 C 1271 |
Chain | Residue |
C | LEU181 |
C | ALA182 |
C | HIS218 |
C | GLU219 |
C | HIS222 |
C | HIS228 |
C | ALA234 |
C | VAL235 |
C | PHE237 |
C | THR239 |
C | TYR240 |
C | LYS241 |
C | ZN1268 |
C | HOH2076 |
C | HOH2122 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D 1271 |
Chain | Residue |
B | SER207 |
B | GLY209 |
B | TYR240 |
B | TYR242 |
D | THR210 |
D | 0231266 |
D | HOH2107 |
D | HOH2108 |
site_id | CC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL D 1272 |
Chain | Residue |
B | LEU181 |
B | THR210 |
B | 0231268 |
D | SER207 |
D | GLY208 |
D | GLY209 |
D | TYR240 |
D | TYR242 |
D | HOH2108 |
D | HOH2109 |
site_id | CC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 A 1272 |
Chain | Residue |
A | ARG110 |
A | HOH2131 |
A | HOH2132 |
A | HOH2133 |
B | ALA167 |
B | HIS168 |
B | GLY169 |
B | ASP170 |
B | PHE171 |
B | ALA173 |
site_id | CC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE SO4 D 1273 |
Chain | Residue |
C | ARG110 |
D | ALA167 |
D | HIS168 |
D | GLY169 |
D | ASP170 |
D | PHE171 |
D | HIS172 |
D | ALA173 |
D | HOH2050 |
D | HOH2110 |
D | HOH2111 |
D | HOH2112 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 1272 |
Chain | Residue |
C | THR204 |
C | THR205 |
C | HIS206 |
C | SER207 |
C | GLY208 |
C | HOH2123 |
site_id | CC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 1273 |
Chain | Residue |
A | ALA167 |
A | HIS168 |
A | GLY169 |
A | ASP170 |
A | PHE171 |
A | HIS172 |
A | ALA173 |
A | HOH2134 |
A | HOH2135 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 1273 |
Chain | Residue |
B | ARG135 |
B | LYS136 |
B | GLN139 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL |
Chain | Residue | Details |
A | THR215-LEU224 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 | |
B | GLU219 | |
C | GLU219 | |
D | GLU219 | |
site_id | SWS_FT_FI2 |
Number of Residues | 76 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP124 | |
A | GLY190 | |
A | GLY192 | |
A | ASP194 | |
A | HIS196 | |
A | ASP198 | |
A | GLU199 | |
A | GLU201 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
A | ASP158 | |
B | ASP124 | |
B | ASP158 | |
B | HIS168 | |
B | ASP170 | |
B | ASP175 | |
B | GLY176 | |
B | GLY178 | |
B | ILE180 | |
B | HIS183 | |
B | GLY190 | |
A | HIS168 | |
B | GLY192 | |
B | ASP194 | |
B | HIS196 | |
B | ASP198 | |
B | GLU199 | |
B | GLU201 | |
B | HIS218 | |
B | HIS222 | |
B | HIS228 | |
C | ASP124 | |
A | ASP170 | |
C | ASP158 | |
C | HIS168 | |
C | ASP170 | |
C | ASP175 | |
C | GLY176 | |
C | GLY178 | |
C | ILE180 | |
C | HIS183 | |
C | GLY190 | |
C | GLY192 | |
A | ASP175 | |
C | ASP194 | |
C | HIS196 | |
C | ASP198 | |
C | GLU199 | |
C | GLU201 | |
C | HIS218 | |
C | HIS222 | |
C | HIS228 | |
D | ASP124 | |
D | ASP158 | |
A | GLY176 | |
D | HIS168 | |
D | ASP170 | |
D | ASP175 | |
D | GLY176 | |
D | GLY178 | |
D | ILE180 | |
D | HIS183 | |
D | GLY190 | |
D | GLY192 | |
D | ASP194 | |
A | GLY178 | |
D | HIS196 | |
D | ASP198 | |
D | GLU199 | |
D | GLU201 | |
D | HIS218 | |
D | HIS222 | |
D | HIS228 | |
A | ILE180 | |
A | HIS183 | |