1ROS
Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid
Summary for 1ROS
Entry DOI | 10.2210/pdb1ros/pdb |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | macrophage metalloelastase, non-zinc chelator, mmp-12, mmp12 inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 2 |
Total formula weight | 37647.43 |
Authors | Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. (deposition date: 2003-12-02, release date: 2004-12-07, Last modification date: 2023-08-23) |
Primary citation | Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J.Mol.Biol., 341:1063-1076, 2004 Cited by PubMed: 15289103DOI: 10.1016/j.jmb.2004.06.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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